Irf3 phosphorylation
WebFigure 7 Proposed model of IRF3 and -7 phosphorylation. Virus-induced dsRNA activates PKR while a second, protein synthesis-dependent step activates an unknown kinase X …
Irf3 phosphorylation
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WebInterferon regulatory factor 3 Show on y-axis -References (HTP + LTP) References (LTP) References (HTP) log2 Transformation. Filter PTM sites. Minimum 5 References Add … WebSep 19, 2024 · For analyzing IRF3 phosphorylation, HEK293T cells were transfected with a plasmid expressing nsp6, nsp13, or ORF6. At 24 hpt, cells were treated with poly(I:C) (a dsRNA mimic) and analyzed for IRF3 phosphorylation (Figure 2A). Nsp6 and nsp13 inhibited 57% and 75% of the IRF3 phosphorylation, respectively.
WebMar 4, 2024 · In this study, by using multiple USP22 knockout mouse models or cells, we identified a previously uncharacterized role of the cytoplasmic USP22 in facilitating virus … WebNational Center for Biotechnology Information
IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found … WebOct 6, 2024 · IRF3 phosphorylation by TBK1 and IKKε leads to its dimerization and nuclear translocation, where it associates with CBP/p300 to initiate transcription of anti-viral target genes, such as type I interferons (TI-IFNs).
WebApr 11, 2024 · Interestingly, while we observed no difference in the phosphorylation of TBK1 between wild-type EHEC- and ΔEhaF-infected cells (Fig. 3h), IRF3 phosphorylation was …
WebIRF3. IRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … fishfest scheduleWebSep 14, 2024 · This was because EGFR had a differential effect on activation of the two transcription factors: IRF3 activation, as monitored by its phosphorylation, was totally blocked by gefitinib, but NF-κB activation, as judged by the phosphorylation and degradation of IkB, was unaffected (Fig EV2 B). fishffffWebAug 3, 2007 · The transcription factor interferon regulatory factor 3 (IRF-3) regulates genes in the innate immune response. IRF-3 is activated through phosphorylation by the kinases … fish fest wheatleyWebApr 11, 2024 · In the TLR4-TRIF-IRF3-type I IFN signaling cascade, phosphorylation of the TBK1 kinase is a key step 2. Phosphorylated-TBK1 (pTBK1) subsequently phosphorylates IRF3, which then translocates... fish fever gameWebOct 22, 2024 · Upon phosphorylation, IRF3 has to leave the adaptor as a monomer and the recently added phosphorylation will be exposed to cellular phosphatases. However, when phosphorylation occurs within these ‘signaling hubs’, IRF3 is likely to meet a similar phosphorylated IRF3 molecule, which allows for the formation of the stable homodimer … fishfffWebDeficiency of STING prevented IRF3 phosphorylation by ethanol or ER stress, and absence of IRF3 prevented hepatocyte apoptosis. The pathogenic role of IRF3 in ALD was independent of inflammation or Type-I interferons. Thus, STING and IRF3 are key determinants of ALD, linking ER stress signaling with the mitochondrial pathway of … can a property manager except a finders feeWebThe induction of phosphorylation of STING on S366 of IRF3 on S396 was inhibited in T404E compared to WT or T404A cells (Fig. 3C). We also found that IRF3 nuclear translocation ( Fig. 3 D and SI Appendix , Fig. S5 B ) and the induction of IRF3-dependent genes ( Fig. 3 E ) were substantially inhibited in cells expressing T404E-STAT2. fish fest treviso