WebJan 13, 2012 · There is biochemical evidence that tacrolimus interacts with the OATP1B1 transporter [85, 86]. However, the reported IC50 values for tacrolimus-mediated OATP1B1 inhibition are close to 4µM... WebJun 2, 2010 · CsA inhibited OATP1B1 mediated uptake of atorvastatin about 90-fold more efficiently than Tac, with half maximal inhibitory concentration (IC 50) values of 0.021 ± 0.004 µM and 1.99 ± 0.42 µM, respectively. Co-incubation as compared with pre-incubation with CsA showed a 20-fold lower inhibitory capacity, with an IC 50 value of 0.47 ± 0.34 µM.
Tacrolimus Injection: MedlinePlus Drug Information
WebJul 5, 2016 · The calcineurin inhibitor tacrolimus is the cornerstone of most immunosuppressive regimens in solid organ transplantation. It is, however, characterized … WebAug 9, 2024 · Generic name: tacrolimus (oral/injection) [ ta-KROE-li-mus ] Brand names: Astagraf XL, Envarsus XR, Prograf, Hecoria. Dosage forms: intravenous solution (5 … macbook trackpad replacement 2011
Cyclosporine A, but Not Tacrolimus, Shows Relevant …
WebTacrolimus: A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. Sorafenib: A kinase inhibitor used to treat … WebStructure-based identification of OATP1B1/3 inhibitors Several recent studies show that inhibition of the hepatic transport proteins organic anion-transporting polypeptide 1B1 (OATP1B1) and 1B3 (OATP1B3) can result in clinically relevant drug-drug interactions (DDI). WebContraindicated. Concomitant use of elagolix and strong OATP1B1 inhibitors is contraindicated. tacrolimus. tacrolimus will increase the level or effect of elagolix by Other (see comment). ... Information suggests voclosporin (an OATP1B1 inhibitor) may increase in the concentration of OATP1B1 substrates is possible. Monitor for adverse reactions ... kitchen shop battle creek